IRON AND ANEMIA / FREE RAD WORKSHEET
Bob Miller, NP ; nutrigeneticresearch.org, #44
NUTRAGENIC RESEARCH INSTITUTE
Software for doctors is available to check if genetic pattern is present in pt.
IRON DYSREGULATION AND SULFHYDRIL RADICAL FORMATION
SUPPORT HYDROGEN PEROXIDE REMOVAL
SUPPORT GLUTATHIONE CREATION & REcycling
O2 + e- = superoxide free radical (O2-.)
Superoxide dismutase has extra e-
(O2-.) + superoxide dismutase (AO) = H2O2
++Fe + H2O2 = Hydroxyl radical (OH.) which damages DNA
= Fentin reaction
[Fe is bound to transferrin in blood and stored in cells to ferritin.]
[All antioxidants = AO = glutathione peroxidase, catalase, thriodoxine, superoxide dismutase]
H2O2 + AO = H2o + o2
FENTIN RX INSIDE ALL CANCER CELLS
LYME , CFS, MCS all have (HF3gene) causes ABSORB EXTRA FE, (SLC48-1 gene) but don’t clear the hydrogen peroxide and collide with fe and make (OH.)
Therefore we must clear the hydrogen peroxide first before giving Fe.
Nutragenic research institute
Software for doctors is available to check if genetic pattern is present in pt. if they over absorb iron and are anemic then hold iron first. Give glutathione creation and recycle. And remove hydrogen peroxide.
GLUTAMATE TO GABA TO SLEEP (CONVERSION BY GAT enzyme)
GLUTAMATE MAKES YOU SMART AND GO GETTER. IF TOO HIGH GLUTAMATE = ANXIETY, INSOMIA
VISUAL AND AUDITORY HALLUCIINATIONS
NADPH= AO= antioxidant
Infection and inflammation inhibits GAT
GLUTATHIONE=GLUTAMINE ===GLUTAMATE ====GABA
GLUTAMATE with alpha ketoglutarate and succyacetyl coA with cofactor NADPH puts energy in cell. This is depleted by inflammation.
Inflammation balance with antioxidants moiu
NRF 2 = NUCLEAR TRANSACTION FACTOR CONTROLS GLUTATHIONE AND (NADPH= AO) PRODUCTION.
Also FE SEQUESTRATION
Lyme effects NRF2 GENE which makes its effects weak and limits glutathione production.
MTOR IS GENE THAT DIRECTS CONSTRUCTIOM OF NEW CELLS. AUTOPHAGY IS CLEANUP GENE CLEARS MOLD AND VIRUSES.
↑MTOR gene with eating (PROTEIN, CARB DIET)
↑AUTOPHAGY gene with fasting, ↓with eating
↑AUTOPHAGY with ↑fat diet and ketosis diet
(Curcumin)Tumuric & Resveratrol INHIBIT MTOR gene
Burbur & lithium ↑ AUTOPHAGE
SCULCAP ↓ FE ABSORPTION
Therefore w pt w upregulation of mtor & nox1
Autophage assist supplement with fasting
MAST CELL ACTIVATION/HISTAMINE OVERACT
HEPARIN IS LIKE A CYTOKINE
OVERACTIVE MAST CELLS= WBC
S/S NOT TOLERATE HEAT OR SOME COLD
MASSAGE SORENESS, OVERREACTION TO MOSIQUITO BITE
Cytocromp450, methylation, acetylation, glucuronication, sulfation,
acetylCoA; acetylation DETOX dysfunction pt has problem with smoke, and exhaust fumes. AND INHIBITION OF RETROVIRUSES. PANTATHINE needs to be present. Pantathine will help pt acetylate and clear histamine, and also promote cortisol production inhibit histamine.
DAO enzyme deficiency therefore unable to clear histamine
HAMT (Histamine methyl transferase) deficiency therefore unable to clear histamine
NADPH (knox Enzyme) which creates the MAST CELLS enzyme stimulated by Mold, EMF, sulfites, homocysteine, high Fe, mTor
Kit genes activates mast cells. Supplement MC BALANCE = BIOFLAVINOID GLUTIOLIN & CURCUMIN►↓NADPE & MTor.
Mast cell degranulation can cause bronchial tubes to cause SOB & PERIPHERAL EDEMA.
PANTATHINE FOR PAN GENE DEFICIENCY ALSO NEEDED FOR PANTATHETIC ACID DEF & THEREFORE NEED FOR ADRENALS AND PREGNENOLONE, and DHEA, CORTISOL.
HEME SYNTHESIS, PORPHYRIAS,
Succinyl CoA + glycine begin HEME Cycle. Enzyme FETCH binds Fe to HEME protein. UNATTATCHED FE BECOMES STRONG FREE RADICAL MAKES PT TIRED AND SICK & HOT.
Roundup =(glypholsate) is effecting the glycine step of the 7 step HEME Cycle. Suox enzyme needs HEME. Suox enzyme changes sulfites into sulfates. THIS EFFECTS SULFATION. HEME IS ALSO RESPONSIBLE FOR CATALASE for Super Oxide Dismutase & NITRIC OXIDE & cytochrome P450 (phase 1 liver detox). HMOX (HEME OXIGENASE) enzyme properly places Fe to store as ferritin.
[With patients with HF3 variance will have over absorption of Fe and with Variance or Mutation of HMOX will also have low ferritin. PT will present with inflammation going on and low ferritin & then when you give them Fe they get worse.]
I’m allergic to sulfites or sulfates = therefore sulfites are excitatory to the brain and ↑ knox enzyme (NADPH). Measure sulfites & sulfates in the urine. See high sulfites. Sulfation like acetylation and methylation, we use it to get rid of our cholesterol and catecholamines. Sulfation if impaired causes ↑estrogen→↑histamine &↑mtor, and ↑catecholamines →↑histamine. Glypholsate can ↓regulate the suox enzyme ↓sulfation →↑knox→↑mast cells→ autism and anxiety.
Kreb Cycle has glycine & SuccinylCoA and if IMPAIRED then PT IS HANGERY (angry & hungry) all the time on ketogenic diet. Porphyrins will block the GABA receptor sites. They will crave ice-cream = sugar and glycine, or energy drink to feed their HEME pathway. Addiction for Need constant carbs to feed HEME PW, thereby blocking their GABA receptor sites and impairing sulfation, and impairing nitric oxide causing chronic cold hands and feet. Erectile dysfunction CytochromeP450.
PT with HEME variances/impairments of HF3; SLC48-1;FETCH, NRF2,HMOX can cause free radical and cause pt to be hot all the time because of Fe FENTON RX.
0.9 % ISOTONIC(QUENTON) KETON WATER= SULFATE WATER
EPSON SALT BATHE
Magnesium sulfate lotions
SUOX WITH MOLEBOLMUN
PT VERY SENSATIVE TO CHEMICALS=heme site is dysrupted
TRACE MINERALS FOR COFACTORS TO DETOX
KNOX ENZYME=NADPH OXIDANTS= RECHARGES ANTIOXIDANTS
[NEED NAD+ TO MAKE NADPH, and stimulates sert1 and sert 3 enzymes. ]
NADPH IS NEEDED TO RECYCLE YOUR GLUTATHIONE, and recycle your thyradoxine, recycle your Nitric Oxide production.
NADPH BALANCE IS KING as we need NADPH to make both free radicals to kill bacteria, cancer, etc. we also need NADPH to recharge our antioxidants: glutathione, SOD .
WHAT IS THE PROBLEM IS NADPH STEAL or is being hijacked by too many environmental factors i.e. sulfites stimulates knox(NADPH). As does TOO MANY chronic infections, EMF, Homocysteine Fe, and Mtor all stimulate knox. AND ALL THIS KNOX STIMULATION towards free radical production over glutathione production stimulates the mast cells. Thus we see over activation of MAST CELLS. As you are creating more free radicals and have less antioxidants to balance it. Causing a vicious cycle towards mast cell degranulation..
IDENTIFY GENOMIC SUSEPTIBILITY, & TX INDIVIDUAL VARIANCES WHILE AT THE SAME TIME REDUCE KNOX ENVIRONMENTAL STIMULANTS FOR FREE RADICAL FORMATION WHILE ALSO TX NADPH with NAD+ PATCHES, NAD IVs, nicotinamide riboside→NAD+→NADH→ENERGY; NAD+→NADPH→for recycling of antioxidants catalase,SOD,GLUTATHIONE. NAD+→SERT3→↑AUTOPHAGE,↑Urea cycle clear NH3
NAD+→SERT 1→↓MTor, ↑VIT D3;
NAD+→↑ PARP → DNA repair
Darc gene to protect against malaria
Dr Miller takes Hanokial for glutamate to GABA conversion, Quercetin to reduce mast cell, Skullcap to reduce Fe absorption, Pantathine to accelerate acetylation to clear histamine, and ↑cortisol which↓Histamine. Ketone diet. Kenton water, Epson salt bathe, MSM, Mag Sulfate creams, CRICIFEROUS VEG., IV Glutatione. Oral glutathione,
Nerf 2 accelerate 2x /wk, autophage assist hs , eat 2 x/d. 23 & ME with added SNPs.